United States Citizenship and Immigration Services
Texas Service Center
4141 North St. Augustine Road
Dallas, TX 75227
Re: Awards given to Dr. _____________
This letter is written to certify that Dr. __________ is a previous winner of the “Shandong Scientific & Technology Progress in Medicine Award” and the “Shandong Scientific & Technology Progress Award,” both of which are prestigious and nationally recognized prizes in China on the basis of the significant contributions to science made by the winners.
I am a Professor of Pediatrics and the vice Director of the Department of Pediatrics at Shandong Provincial Hospital, Shandong University in China. Shandong University is one of the top universities in China and enjoys an international reputation for its outstanding academic and scientific research achievements. I have been working at this University for more than 2 decades, and my research interest is autoimmune diseases, such as asthma and myocarditis. I have published 52 scientific papers in peer-reviewed national and international journals. I am currently the vice Chairman of the Shandong Province Immunologists Association. For many years, I have served as Chair or a Member of the prize selection committee for reviewing nominations and selecting the annual winner of the “Shandong Scientific & Technology Progress in Medicine Award” and the “Shandong Scientific & Technology Progress Award.”
The process of selecting winners for these awards is rigorous and the competition for the awards is very intense. Each year, for example approximately 3000-3500 applicants compete to be 1 of 100 winners of the “Shandong Science & Technology Progress in Medicine Award.” The applications are first evaluated by a panel of local experts in their fields. Based on their work, the applicants are scored by these experts, and the top 5 are then submitted to the prize selection committee, which is comprised of 15 national and international experts in their fields. To be a winner of these awards, candidates must satisfy the following criteria: 1. Their work must show creativity and originality or demonstrate significant progress in improving existing technology; and 2. Their work must greatly benefit the national or international communities. To satisfy the above criteria, candidates must 1. Be recommended by 5 experts who are familiar with the work; and 2. Present their patents or publications.
Being the recipient of these awards is tangible and concrete proof to demonstrate a scientist exceptional status. Dr. __________ won the “Shandong Science & Technology Progress in Medicine Award” in 1996 for his work “The correlation study of the deficiency of serum Immunoglobulin G subclasses and trace elements with recurrent respiratory tract infection in children” and he won the “Shandong Science & Technology Progress Award” in 1998 for his work, “The clinical study of cytokines (interleukin-6, interleukin-8, tumor necrosis factor and interferon-y) and immunoglobulin G subclasses in children patients with bronchial asthma.” Bronchial asthma and recurrent respiratory tract infection are very common diseases among children in China. Bronchial asthma usually results from an abnormally high level of immune response to infection. It has been reported in western countries that multi-factors contribute to the onset and development of these diseases. In China, around 5-10% of children ages 2 to 13 suffer from bronchial asthma or recurrent respiratory tract infection. Before Dr. ____________, the prevalent therapies for these diseases were mainly adopted from western countries. However, these treatments were proven in practice not to be completely successful in treating children with these diseases. Thus, there was a critical need for thoroughly understanding the disease background in order to find ways for designing improved therapies for patients with bronchial asthma and recurrent respiratory tract infection.
In the study of “The correlation study of the deficiency of serum Immunoglobulin G subclasses and trace elements with recurrent respiratory tract infection in children,” Dr. _______ et al, identified the blood level of zinc as a key factor for disease susceptibility. They found that the Zinc level in blood from children with recurrent respiratory infection is always much lower than that from healthy control children. Zinc is essential element necessary for sustaining life. Dr. _________ et al first reported a correlation between the level of zinc and the immune capability of a child. For individuals with low levels of Zinc in their blood, their Immunoglobulin G was usually deficient in some subclasses or less in total amount. Immunoglobulin G activates the complement immune system to destroy these pathogens, thereby protecting body against such pathogens. Dr. _________ et al found that children with low Zinc levels are readily subjected to respiratory tract infections. Notably, Dr. __________ and his colleagues found that after given zinc treatments, the deficiency of Immunoglobulin G in patients with recurrent respiratory infection gradually disappeared and patients gradually recovered from disease. Based on Dr. finding, pediatricians in China now always apply Zinc treatment as a supplementary therapy to children with recurrent respiratory infection. Based on this finding, Dr.__________ was awarded the “Shandong Science & Technology Progress in Medicine Award” in 1996.
In the study of “The clinical study of cytokines (interleukin-6, interleukin-8, tumor necrosis factor and interferon-y) and immunoglobulin G subclasses in child patients with bronchial asthma. The immune system is a complicated a network comprised of a variety of immune cells and immune proteins such as cytokines and immunoglobulin. All of these factors regulate each other to maintain a well-balanced immune system, which functions normally to defend against foreign pathogens and tolerate the body’s own cells. On the other hand, an unbalanced immune system will inevitably result in infection or autoimmune diseases. Asthma is a kind of autoimmune disease involved the respiratory system due to severe inflammation caused by an immune response. In children with asthma, Dr. _________et al found the immune system in such patients is skewed. These patients had more Th2 T cells and their ratio of the Th2/Th1 is higher than in healthy children. These patients also contained high levels of interleukin-6, interleukin-8 and Tumor-neurosis-factor-α. As a result of these abnormal immune factors, when the immune system in these individuals is stimulated, it mounts a response that causes severe inflammation in tissues around the respiratory tract. Inflammation results in producing too much mucus which blocks the airway and releases chemicals to constrict the airway.
In this study, Dr. et al suggested that therapies for bronchial asthma should aim at returning balance to the immune system. Based on this work, Dr _________ was awarded the “Shandong Science & Technology Progress Award” in 1998.
Please do not hesitate to contact me if further information is needed.
Department of Pediatrics
Shandong Province Hospital, Shandong University